You should make sure your Firewall allows access for the following ports:

Port/Protocol/Direction/Description
--------------------------------

21 TCP Out - FTP out for retrieval of system updates.
22 TCP Out - SSH access to allow SpamTitan support a secure connection to the appliance for support.
25 TCP Out - SMTP to send email.
25 TCP In - SMTP to receive email.
80 TCP Out - Clam and Kaspersky virus definition updates are retrieved via HTTP.
53 UDP Out - DNS.
123 UDP Out - NTP if using time servers outside your firewall.

873 TCP Out - Used to get the 'flag' information on the dashboard for virus and spam relays.

2703 TCP Out - Razor Checks the checksum or signature of mail messages against the Razor lists.
24441 TCP & UDP Out - Pyzor Checks the checksum or signature of mail messages against the Pyzor lists.


Cluster Only

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5432 TCP - Used for clustering of history and quarantine data.